Introduction: Saroglitazar is known to safely and effectively improve dyslipidemia by reducing triglyceride (TG), low density lipoprotein (LDL) cholesterol, very low-density lipoprotein (VLDL) cholesterol, non-high-density lipoprotein (non-HDL) cholesterol and increasing high density lipoprotein (HDL) cholesterol. In addition, saroglitazar can improve glycemic indices in diabetic patients by reducing fasting plasma glucose (FPG) and glycosylated haemoglobin (HbA1c). Aim of the study was to evaluate the hospital based clinic-pathological profile, diagnosis, treatment and follow up of Indian patients with Non-alcoholic fatty liver disease and to evaluate the safety and efficacy of Saroglitazar 4 mg in patients with Non-alcoholic fatty liver disease /Non-alcoholic Steatohepatitis in real life setting. Material and methods: This was an ongoing observational study with the sample size of 52 patients having Nonalcoholic fatty liver disease and dyslipidaemia with or without Type 2 Diabetes Mellitus and treatment follow up for a period of 1 year in the Department Of Gastroenterology. The data was collected from eligible patients who have been prescribed Saroglitazar 4 mg once daily in routine clinical practice. Primary endpoints were to see liver stiffness. Secondary endpoints were to measure serum alanine aminotransferase, aspartate aminotransferase level and Serum triglycerides level. Results: There was a significant decrease in Serum alanine aminotransferase (p <0.001), aspartate aminotransferase (p value < 0.001), triglycerides (p value <0.001) and triglycerides (p value 0.01), levels after the treatment as compared to the baseline. Conclusion: Saroglitazar treatment is effective and there is a significant difference in Serum alanine aminotransferase and aspartate aminotransferase, triglycerides and Liver Stiffness Measurement levels after treatment. The drug can be successfully administered for the treatment of Non-alcoholic fatty liver disease.

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