No abstract

Background: Preeclampsia occurs in 7 to 10% of pregnancies worldwide. At present most, popular theory is an oxidative stress. Abnormal lipid profiles and species may have a role in promotion of oxidative stress and vascular dysfunction seen in pre-eclampsia. Objectives of this study was carried out to evaluate lipid profile in subjects with preeclampsia and to compare lipid profile in subjects of preeclampsia as compared to normal pregnant women.Methods: A comparative longitudinal study was conducted under the tertiary care hospital setting over a period of one year where 440 study subjects were enrolled out of which 220 subjects were pre-eclamptic and 220 subjects were normotensive with gestation of 28 weeks to till term. Lipid profiling was done in all the subjects.Results: The mean serum levels of total cholesterol (198.5±18.91), HDL (50.63±9.35), LDL (84.5±16.16), VLDL (42.75±4.72) and TGA (74.92±11.95) were higher in pre-eclampsia group compared to normotensive group and this difference in the levels of lipid parameters was found to be statistically significant.Conclusions: Dyslipidemia is significantly evident in preeclampsia and plays an important role in its pathogenesis.

Background: To study the correlation between maternal body mass index (BMI) with maternal and perinatal outcome in women admitted to labour ward in Department of OBG, VIMS, Ballari.Methods: This observation study was conducted in Department of OBG, VIMS, Ballari for a period of one year between 1st October 2014 to 30th September 2015. All women admitted to labour ward with full term singleton pregnancy were included in the study. The cases were classified into four groups as under-weight (BMI <20kg/m2), normal (BMI 20-24.9kg/m2), over-weight (BMI 25-29.9kg/m2) and obese (BMI >30kg/m2). The maternal and perinatal outcome noted and studied in the above groups.Results: A total of 500 cases were included during the study period of one year, out of which 15% were under-weight, 68% were normal BMI, 12% were over-weight and 5% cases were obese(BMI >30kg/m2). The patients with low BMI had higher incidence of low birth weight (40%) and perinatal deaths. Increased BMI category was associated with higher incidence of PIH (25-28%), operative deliveries (50-68%), PPH (12%), microsomal babies (32%), low APGAR (24%) and perinatal deaths (12%).Conclusions: Adverse maternal and perinatal outcomes are significantly related to extremes of BMI categories and least complications were seen in normal BMI group.