Diabetes mellitus (DM) is a group of metabolic diseases characterized by chronic hyperglycemia due to defects in the mechanism for insulin secretion. The low insulin levels to achieve adequate response and insulin resistance of target tissues and effector enzymes or genes are responsible for these metabolic abnormalities (Kharroubi & Darwish, 2015;Raffel & Goodarzi, 2014). The glucose uptake in muscle cells could process by various mechanism pathways.The common mechanism, such as AMP-activated protein kinase (AMPK) and insulin-regulated glucose transporter (GLUT), plays an essential role in regulates cellular metabolism (Musi et al., 2001). AMPK-α1 is commonly distributed in various cells, and AMPK-α2 is available expressed in the heart, liver, and skeletal muscle (Long & Zierath, 2006). Glucose transporters transfer glucose from the extracellular space (derived from the bloodstream) through cells.The glucose reduced in the blood results of insulin action. Via the GLUT2, glucose joins the β-cells in the pancreas, and this is a significant trigger that contributes to the release of insulin that enters the bloodstream (Stein & Litman, 2015).