Background: Transcription factor 7-like 2 ( TCF7L2 ) gene has a significant role in hyperglycemia in pregnancy (HIP) risk. The current study was planned with the aim to evaluate the association of single nucleotide polymorphism (SNP) rs7903146 in patients of newly detected HIP among Indian population of northern region. Methods: This study was an observational case control study done among newly detected HIP (The World Health Organization (WHO) criteria, 2013) and healthy pregnant females without diabetes. Participants from both the group were genotyped for rs7903146 (C/T) variant of TCF7L2 gene using polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) technique. Results: A total of 71 cases of newly detected HIP were included in the study, out of which 25 (35.2%) of them were of first-time detected diabetes mellitus in pregnancy (DIP) and 46 (64.7%) were of gestational diabetes (GDM) and 100 were pregnant females without diabetes in third trimester were enrolled as controls. Average age of participants in the case group was 28.7 ± 4.0 years and the control group were 26.5 ± 3.6 years ( P value 0.09). The wild homozygous CC genotype, heterozygous CT genotype and homozygous TT genotype were present in 39.4%, 53.5%, 7.1% of case group vs 53%, 43% and 4% of control group, respectively. No significant association of rs7903146(C/T) SNP of TCF7L2 gene in HIP (CC/CT, CC/TT P value 0.15, 0.38, respectively) in our population was found. There was no significant difference in the distribution of genotypes between DIP and GDM. Conclusion: This study shows no evidence of association of rs7903146(C/T) SNP of TCF7L2 gene with newly detected HIP in our population.

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Background: In India, 89 million preschool children (6-59 months) suffer from anaemia. As per NFHS-4, the prevalence of anaemia in Uttar Pradesh was 63.2%. A study was undertaken to estimate the prevalence of anaemia among preschool children and to examine rural-urban differentials and association of socioeconomic determinants with anaemia. The secondary data of the National Family Health Survey-4 conducted in the year 2015-16 was used.Methods: The prevalence of anaemia was calculated and chi-square test and binary logistic regression was carried out to identify the association between anaemia status and socioeconomic factors.Results: Results show that 78% and 77% children in 12-23 months age group were anaemic in urban and rural areas respectively. Around 72% and 65% children whose mothers had no formal education were anaemic in urban and rural areas respectively. Around 73% of children belonging to poorest wealth index in urban areas and 64% belonging to poorer wealth index in rural areas were anaemic. Around 70% children whose mothers had anaemia were anaemic in both urban and rural areas of the state.Conclusions: The association between anaemia in preschool children and different socioeconomic variables was profound.  Educational status of mother and anaemia in mothers have a significant role in reduction of anaemia.  The socioeconomic conditions of households, education level of mothers and their anaemia status need to be improved to reduce anaemia in preschool children in Uttar Pradesh and it requires immediate attention of planners and policy makers.