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The diagnosis and monitoring of SARS-CoV-2 infection (COVID-19 illness) are based on two different types of tests: (i) RT-PCR (reverse-transcription polymerase chain reaction) test that detects the presence of viral RNA, and (ii) antibody test that detects antibodies to SAR-CoV-2. Studies have demonstrated that antibody testing is useful for the identification of asymptomatic or subclinical infection of SARS-CoV-2 among close contacts with COVID-19 patients, including the HCP.This study presents the first SARS-CoV-2 seroprevalence study among 307 HCP in Central India. This study also evaluates the risk of exposure of the HCP of different roles/departments to COVID-19 infection by the SARS-CoV-2 antibody seroconversion rate. A cross-sectional study was conducted using serum obtained from 307 HCP, who were on duty in the hospitals in Indore City of Central India during the COVID-19 pandemic from March till June 2020. Siemens Healthineers COV2T assay that detects total antibody (including IgM and IgG) against the S1-RBD (receptor binding domain of spike protein subunit 1) antigen was selected to be used in this study due to its robust sensitivity and specificity, compared to IgG or IgM assay alone Overall, the prevalence of COVID-19 infection among HCP in Central India hospital is 7.82% (n=24/307) as evaluated using SARS-CoV-2 total antibody test. Of the 307 HCP. Seropositivity rate varies widely by professions/departments ranging from intensivists (66.7%), general surgeons (25%), ophthalmologist (20%), pediatrician (20%), anesthetist (12.5%), radiologist (10%), general physician (9.7%) to gynaecologist (4.9%). This seroprevalence study, along with other studies, highlights the importance of SARS-CoV-2 antibody in seroprevalence and epidemiology studies which may subsequently guide the policy-making in implementing an effective infection control strategy to curb SARS-CoV-2 transmission in the hospital settings; on top of the use as aid-in-diagnosis, contact-tracing, pre and post vaccination screening and evaluation of convalescent plasma therapy.

BACKGROUND One of the important causes of morbidity and mortality in paediatric population is Congenital Heart Disease (CHD). Genetic, environmental and cultural factors may lead to variability in prevalence and incidence. (1) There are many modalities for the diagnosis of CHD, in our armamentarium. Echocardiogram is the first in cases suspicious of CHD. However quite often, it is difficult to access and evaluate great arteries, pulmonary veins, coronary arteries and intracardiac anomalies in detail. In seriously ill or uncooperative patients, magnetic resonance imaging (MRI) is often of limited use. MRI examination also takes longer duration, causes claustrophobia and electronic devices such as pacemakers are a contraindication. (2) METHODS In this retrospective observational study 21 cases of clinically diagnosed Tetralogy of Fallot's (TOF) referred to Sodani Diagnostic Centre, Indore and matching our inclusion and exclusion criteria, were included in this study. Out of 21 subjects, 9 were female and 12 were male. Youngest was 9 months old and eldest was 30 years old. Most of the study subjects were sent investigation of the morphology of heart and great vessels using cardiac CT, as echocardiography was not enough. All studies were performed on 128 Slice GE Optima after taking consent. RESULTS In our study, a 128 slice multidetector CT scanner GE Optima was used, to scan 21 patients with TOF. Defect in ventricular septum (VSD) was noted in all cases (n =21). Overriding of aorta was noted in nineteen patients (90%). Right ventricle was mildly hypertrophied (RVH) in 10 patients (47%). 8 patients (33%) were showing major aorto-pulmonary collateral circulation (collateral diameters ranged from 1 to 3.5 mm) and narrowing of pulmonic infundibulum was seen in 7 patients (28%), aortic arch was right sided in 5 cases (23%). Complex pulmonary artery morphology was seen in most of the patients. Pulmonary trunk and bilateral pulmonary arteries were significantly narrowed in 3 cases (14%). Stenosis of main trunk and left pulmonary artery were noted in 2 cases (9%). Right pulmonary artery and main trunk narrowing was seen in 4% (n=1). CONCLUSIONS Important additional information is obtained by using technically advanced Multidetector CT. Newer advances have significantly increased the speed of CT machines, so we can complete the procedure of pulmonary CTA with ease of peripheral venous access and markedly reduced sedation time. No correlation was found between size of pulmonary trunk and collaterals, which suggests that every patient has different chance of detecting collaterals. However as age increases, chances of getting collaterals also increases.

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