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Introduction A series of atypical acute respiratory diseases were caused in Wuhan, China in December 2019 by a novel coronavirus (COVID-19). Over six million confirmed COVID-19 cases have been reported worldwide and total deaths in the USA from 1 March to 30 May 2020 were approximately 7,81,000. Worldwide scientists are developing many potential COVID-19 vaccines. Few of the companies got success in the development of a vaccine for COVID-19 but most of the recipients reported injection site reactions like pain, redness, or erythema after vaccination. The present study aimed to evaluate the effect of gentle upper limb exercises to reduce injection site reactions and here we present a case with post vaccination site reaction that reported pre-assessment score 7 for visual analog scale for pain and score 2 for redness and erythema with Investigator-reported and rated injection site reactions. Then he performed gentle upper limb exercises after 8 and 24 hours of vaccination. Result The study reported a beneficial effect of these exercises to reduce pain and redness or erythema after Covid-19 vaccination. Discussion The potential benefit of gentle exercises may be due to their blood flow boost-up and anti-inflammatory effects. However, high-quality controlled trials are warranted further to evaluate the potential benefit of upper limb gentle exercises for the reduction of injection site reactions after the Covid-19 vaccination injection. Conclusion The clinical experience with the subect shows that gentle exercises for upper limb may reduce the inection site reaction after COVID-19 vaccination.

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