Diabetic Retinopathy (DR) is considered as the complication of Diabetes Mellitus that damages the blood vessels in the retina. This is characterized as a serious vision-threatening problem in most of the diabetic subjects. Effective automatic classification of diabetic retinopathy is a challenging task in the medical field. The feature extraction plays an eminent role in the effective classification of disease. The proposed work focuses on the extraction of Haralick and Anisotropic Dual-Tree Complex Wavelet Transform (ADTCWT) features that can perform reliable DR classification from retinal fundus images. The Haralick features are based on second-order statistics and ADTCWT reliably extracts the directional features in images. The proposed work concentrates on both binary classification as well as multiclass classification of DR. The system is evaluated across various classifiers such as Support Vector Machine (SVM), Random Forest, Random Tree, J48 classifiers by giving input image features extracted from the MESSIDOR, KAGGLE and DIARETDB0 databases. The performances of the classifiers are analyzed by comparing specificity, precision, recall, False Positive Rate (FPR) and accuracy values for each classifier. The evaluation results show that by applying the proposed feature extraction method, Random Forest outperforms all the other classifiers with an average accuracy of 99.7% and 99.82% for binary and multiclass classification respectively. INDEX TERMS DR binary classification, DR multiclass classification, retinal fundus images, HARALICK, ADTCWT, 10-fold cross validation. S. GAYATHRI received the B.Tech. degree in electronics and communication engineering from the Vivekandha College of Engineering, under Anna university, Chennai, in 2012, and the M.Tech. degree in advanced communication and information systems from the Rajiv Gandhi Institute of Technology, under Mahatma Gandhi University, Kottayam, in 2014. She is currently pursuing the Ph.D. degree in biomedical image processing with the National Institute of Technology at Tiruchirappalli, Tiruchirappalli, India. Her research interests include bio medical signal and image processing, machine learning, and deep learning.
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