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Abstract. MNISIKLIS is an integrated system aiming to provide universal, indoor location-based services focusing on navigation. This paper presents the overall MNISIKLIS architecture and certain implementation details. In the context of the Design for All approach, the system targets to the support of several types of users, including persons with disabilities as well as elderly, by exploiting multimodal interaction. Moreover, the system implements efficient path finding algorithms and provides advanced user experience through highly personalized services. MNISIKLIS adopts Semantic Web technologies (e.g., ontologies and reasoning methods) for representing and managing application models. Furthermore, MNISIKLIS exploits modern positioning techniques in order to achieve high quality positioning. The paper discusses the algorithms and the models that accommodate the services provided by the system. Additionally, an analysis of the positioning subsystem, the user interaction subsystem and the peripheral infrastructure is given. Hence, a new paradigm in the area of location-based systems is presented.