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Twenty proven cases of amoebic liver abscess were treated at random with either tinidazole or metronidazole. The dose of both was 2 g once daily for 2 days. Clinical, radiological, and biochemical follow-up was done for 30 days. Of the 19 patients who completed the trial, complete recovery was observed in all 10 patients given tinidazole and in 5 of 9 patients given metronidazole (p=0.05). Moreover, patients on tinidazole required repeat aspirations less frequently than those on metronidazole. Mild gastrointestinal side-effects occurred in 1 patient on metronidazole. The results suggest that tinidazole is a more efficacious drug than metronidazole, with rapid therapeutic effect.

To study the effectiveness of Nd: YAG laser peripheral iridotomy (LPI) in whole spectrum of primary angle closure disease including primary angle closure suspect (PACS), primary angle closure (PAC) and primary angle closure glaucoma (PACG). Materials and Methods: It's a retrospective analysis of 171 eyes (87 patients) of primary angle closure disease who have undergone laser peripheral iridotomy (LPI) after proper prelaser evaluation. Patients with prior LPI, glaucoma surgery and secondary glaucoma were excluded. Results were analysed for IOP control, progression of disease and need of antiglaucoma medicine or surgery following LPI. Results: Out of 171 eyes of angle closure diseases, PACS was observed in 23 eyes, PAC in 51 eyes and PACG in 97 eyes. Overall progression was 23.97% (41 amongst 171 eyes) and none of the eyes with PACS shown progression. In PAC group, 5 eyes (9.8%) progressed to PACG and were managed on one antiglaucoma drug. In PACG group of 97 eyes, 36 eyes (37.11%) progressed and managed surgically while 61 (62.89%) eyes did not show any progression. Out of 61 non progressed PACG eyes, IOP was controlled without medication in 14 eyes (29.2%), with one anti glaucoma drug in 17 eyes (27.8%), and with 2 or more drugs in 30 eyes (49.18%). Conclusion: LPI is a very good treating modality, especially in PAC & PACS cases, but in PACG with medical treatment, it is a good tool. Majority of the patients included in the study did not show any disease progression and remained stable following LPI.

To study the changes in keratometric values after pterygium excision with conjunctival autograft in different grades of pterygium. A retrospective, comparative study was done on 75 patients of various grades of pterygium who underwent excision surgery with conjunctival autograft. Preoperative and postoperative details of all the patients on 1, 7 and 30 day were taken into account including detailed ocular examination, best-corrected visual acuity, slit-lamp biomicroscopic examination, keratometric details and posterior segment examination. Net astigmatism was calculated preoperatively and on post-op examinations. Mean of difference in preoperative and post operative net astigmatism is calculated and compared in different grades of pterygium. Our study showed that there are significant changes in net astigmatism after pterygium excision mainly in grade 3 pterygium. Difference in mean net astigmatism at the end of 1 month from preoperative values was 2.39±0.73 in Group C, 1.45±0.5 in Group B and 0.49±0.24 in group C and this difference is significant. The amount of keratometric astigmatism is proportional to grades of pterygium (size of pterygium) and pterygium excision reduces the induced astigmatism and it varies according to grades.