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Mucoadhesive buccal films containing carvedilol were prepared using the solvent casting method. Sodium alginate was used as bioadhesive polymer and different ratios of sodium alginate to PVP K-30 were used. Drug: HPβ-CD complex was incorporated in the buccoadhesive film to improve the dissolution of poorly water soluble drug from the polymeric film. The films were evaluated for their physical characteristics like mass variation, drug content uniformity, folding endurance, in vitro mucoadhesion strength, in vitro mucoadhesion time, surface pH, in vitro drug release, and in vitro buccal permeation study. Films exhibited controlled release for a period of 8 h. The release rate from optimized film best fitted Korsemeyer and Peppas (R 2 =0.9996), followed by zero order (R 2 =0.9963) and the value of n =1.1655 indicated that release from film followed Super Case II transport. The optimized film was subjected to stability study and histopathological examination on porcine buccal mucosa. Also the film was found to be stable in human saliva, no color change was observed. Histopathological studies revealed no effect on the mucosal histology after application of film for 10 hrs. The optimized formulation

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