KRS-Online system is a web-based information system to assist the process of preparing the KRS of every student in University of Muhammadiyah Malang. In this research, the level of usability of the system will be measured and the relationship between the independent variables (usefulness, ease of use, and ease of learning) and dependent variable (satisfaction), either simultaneously or partially, will be analyzed. Usability measurement adopted in this study is USE questionnaire that contains usefulness, ease of use, ease of learning, and satisfaction variables. This research involves 100 respondents from the KRS-Online system users. The result shows that measuring usability produces feasibility of 73.312%, which means usability of KRS-Online system is "acceptable". On the other hand, this study proves that there is a significant influence between usefulness, ease of use, and ease of learning variables with the satisfaction variable simultaneously. In addition, usefulness and ease of use variables significantly affect the satisfaction variable partially, while the ease of learning variable does not significantly affect the satisfaction variable. Intisari-Sistem KRS-Online merupakan sebuah sistem informasi berbasis web yang berguna untuk membantu proses penyusunan KRS setiap mahasiswa Universitas Muhammadiyah Malang. Dalam makalah ini akan diukur tingkat usability system dan dinalisis hubungan antara variabel bebas, yaitu usefulness (kebergunaan), ease of use (kemudahan penggunaan), dan ease of learning (kemudahan mempelajari) terhadap variabel terikat, yaitu satisfaction (kepuasan) secara simultan maupun parsial. Pengukuran usability dalam makalah ini mengadopsi kuesioner USE yang memuat variabel usefulness, ease of use, ease of learning, dan satisfaction. Pengambilan data melibatkan 100 responden dari pengguna sistem KRS-Online. Hasil analisis menunjukkan bahwa pengukuran usability menghasilkan nilai persentase kelayakan sebesar 73,312 yang berarti usability sistem KRS-Online memiliki nilai "layak". Di sisi lain, dibuktikan bahwa terdapat pengaruh yang signifikan antara variabel usefulness, ease of use, dan ease of learning terhadap variabel satisfaction secara simultan. Selain itu, secara parsial variabel usefulness dan ease of use berpengaruh secara signifikan terhadap variabel satisfaction, sedangkan variabel ease of learning tidak berpengaruh secara signifikan terhadap variabel satisfaction.