<p class="abstract"><strong>Background:</strong> Carcinoma of the breast from the very beginning has been a feared disease. Advanced disease is treated by neoadjuvant chemotherapy (NACT). With this, a study was conducted to evaluate the pathologic response to NACT in locally advanced breast cancer.</p><p class="abstract"><strong>Methods:</strong> Study was conducted in GSL Medical College, approved by institutional ethics committee, females aged &gt;18 years with locally advanced breast cancer were included in the study. Female &lt;18 years and breast cancer male were not considered. The dimensions are marked and size of the lump compared before and after NACT. Chi-square test was used to find out the significance of study parameters; p&lt;0.05 was considered statistically significant.</p><p class="abstract"><strong>Results:</strong> Total 110 patients were included in the study, mean age was<strong> </strong>50.63±10.76 years and 53% were in pre menopausal women. When pathological response was considered, 12.7% had complete response, 66.4% had partial response and 20.9% had no response to NACT; statistically there was significant difference between pre and post treatment tumor sizes (p&lt;0.05).</p><p class="abstract"><strong>Conclusions: </strong>Most of the individuals belonged to premenopausal group. Tumour size showed significant decrease after NACT. The overall response rate (complete and partial) after NACT was significant in our study group.</p>