The purpose of this research is to increase the understanding of the principles of forming different types of hubs as spaces for collaborative R&D and innovation. This article offers valuable new knowledge regarding the establishment of hubs as part of the local innovation ecosystem. The paper will, through a qualitative multiple case study, shed light on the research issue of the establishment of hubs through an analysis of empirical data collected from three different types of hubs: a research hub, knowledge hub, and innovation hub. As a result, we introduce new building blocks of hubs to support managers and practitioners in forming collaborative hub structures.