Introduction: Osteoarthritis (OA) represents a failure of the di-arthrodial, synovial lined joint. Among the elderly, knee Osteoarthritis is the leading cause of chronic disability [1] . Because of the increased lifespan and obesity the prevalence of osteoarthritis is in the rise in India. Aim of the Study: Whether platelet rich plasma is useful in OAknee or not. Objectives: To evaluate the role of Autologous Platelet Rich plasma (APRP) in the treatment of patients presenting with primary osteoarthritis and to analyze whether it could be a cost effective disease modifying measure. Materials and Methods: Total 100 OA Knee cases are selected from the Katuri Medical College and Hospital, randomly. First 50 were given A PRP injection to the OA Knee, Next 50 were given normal saline. Platelet-Rich Plasma: Platelets are cytoplasmic fragments of megakaryocytes, that are formed in the marrow [26] and are approximately 2 μm in diameter. They contain more than thirty bioactive proteins, of which many of them have a fundamental role in hemostasis or in tissue healing [28] . Fundamental protein growth factors which are actively secreted by platelets will initiate all the wound healing process [29] PRP includes three proteins in blood which is known to act as cell adhesion molecules: Fibrin, fibronectin and vitronectin [30] . Discussion: Osteoarthritis is a disorder of synovial joints characterized by focal loss of hyaline cartilage with proliferation of new bone and remodeling of joint contour, mainly due to uncoupling of balance between cartilage regeneration and degeneration. Osteoarthritis is a dynamic repair process of synovial joints that may be triggered a variety of insults. We in our study had randomly chosen 100 patients with classic findings of Osteoarthritis and divided them in to two groups. Both the groups were comparable on baseline characteristics of age, height, weight, BMI, pre injection WOMAC score. Fifty of these patients were administered an intra articular injection of Platelet Rich Plasma and other fifty received Normal Saline. The Efficacy of Platelet Rich Plasma in reducing pain, stiffness and physical function were assessed and scored on WOMAC index for both study and control group. The Results were analyzed using unpaired 't' test and chi-square test. Age distribution revealed mean age in group I to be 53.14 and the mean age in Group II was 53.68. Outcome Analysis: The study group and the control group are advised to follow up at 6 weeks, 3 months and 6 months. Outcome analysis for the efficacy was done for reduction in pain, reduction in stiffness and improvement in physical function using WOMAC scale. The Patients were also assessed for reduction in pain using Visual analog scale both at pre injection and at 6 months post injection. Conclusion:Our study has thrown up an interesting choice of treatment modality using Platelet Rich Plasma in the treatment of Knee Osteoarthritis and it has proved efficacious in the observation period of six months.

Healing of non-union infected fracture bones like tibia is a challenging one. Ilizarov external ring fixation is the appropriate method. The aim of our study is to evaluate the efficacy of Ilizarov external ring fixator in infected nonunion of bones and functional results in 20 patients and to conduct the study of complications. The age group included in our study were between 30 to 40 years of the 20 cases 17 were males and 3 were females. Of the 20 cases in our study, 14 cases had excellent results, 4 cases had good outcome, 1 patient had fair outcome, 1 cases had poor outcome. The study shows that Ilizarov ring external fixator system is ideal for limb salvage in infected nonunion of long bones.

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Background: Osteoarthritis (OA) is a major cause of disability among elderly population. It is a major cause of a burden on the health system and its incidence and prevalence continues to rise with a rapidly increasing aging population. Total hip replacement is considered one of the most important and successful intervention in the recent era. The study aims to determine the functional outcome and the complications associated with uncemented total hip replacement using modular prosthesis. In this study 32 cases with osteoarthritis of hip joint were treated by uncemented total hip replacement at Katuri medical college and hospital, China kondrupadu, Guntur between June 2015 to November 2016 were included. The functional outcome is assessed and compared with other studies. The aim of procedure is to assess the functional outcome of uncemented total hip replacement. Materials and Methods: Our study is prospective study of clinical and radiological analysis of uncemented total hip arthroplasties performed for various hip disorders. All patient data and clinical history were noted with reference to pain, range of motion, gait, activities or function (Harris Hip Score). Cementless acetabular components, cementless femoral components are used in this study. Results: All 32 patients in the present study returned for clinical and radiological examinations subsequently. Patients were reviewed after 6 weeks, 3 months, 6 months and 1 year post operatively. The age ranges from 32-60 years with mean age of 48.31 years. Most of the cases are between the age group of 51-60 years constituting 46.88% of study population. Of the 32 cases, male patients 22 constituting 68.75% and the rest 10 are female patients constituting 31.25% of the cases. Conclusions: Our study supports the usge uncemented THR in osteoarthritis in both young and elderly. The current trend, research and advent of new implants support uncemented THR in patients suffering from this crippling hip arthritis and avascular necrosis.