This paper proposes two methods for the compression of biological sequences like DNA/RNA. Although many algorithms both lossy and lossless exist in the literature, they vary by the compression ratio. Moreover, existing algorithms show different compression ratios for different inputs. Our proposed methods exhibit nearly constant compression ratio which helps us to know the amount of storage needed in advance. For the first method, we call it CryptoCompress, we use a blend of Cryptographic hash function and partition theory to achieve this compression. The second method, we call it RefCompress, uses a reference DNA for compression. This paper showcases that the proposed methods have constant compression ratio compared to most of the existing methods.

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