Background & Aims-Eosinophilic esophagitis (EE) is an increasingly recognized disease that mimics gastro-esophageal reflux disease. Recently, EE has been associated with esophageal remodeling, but the mechanisms involved are poorly understood. We hypothesized that the development of EE in patients and in an experimental murine model would be associated with eosinophil-mediated tissue remodeling.
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