No abstract

Although tremendous progress has been made in conventional treatment for ischemic heart disease, it still remains a major cause of death and disability. Cell-based therapeutics holds an exciting frontier of research for complete cardiac recuperation. The capacity of diverse stem and progenitor cells to stimulate cardiac renewal has been analysed, with promising results in both pre-clinical and clinical trials. Mesenchymal stem cells have been ascertained to have regenerative ability via a variety of mechanisms, including differentiation from the mesoderm lineage, immunomodulatory properties, and paracrine effects. Also, their availability, maintenance, and ability to replenish endogenous stem cell niches have rendered them suitable for front-line research. This review schemes to outline the use of mesenchymal stem cell therapeutics for ischemic heart disease, their characteristics, the potent mechanisms of mesenchymal stem cell-based heart regeneration, and highlight preclinical data. Additionally, we discuss the results of the clinical trials to date as well as ongoing clinical trials on ischemic heart disease.

This is an investigation of the distribution of the local rate of mass transfer from 4.2-in-diam naphthalene cylinders to air at ordinary temperature and pressure, flowing normal to the axis. The air speeds are near and within the critical zone of the drag. The results in the laminar region are compared with approximate boundary-layer calculations of H. Schuh and of H. J. Merk and with corresponding heat and mass-transfer experimentation in the literature. It is shown that the calculations after Merk are reliable from the point of stagnation to the predicted point of separation.