No abstract

A straightforward, rapid and efficient one‐pot method was developed for the synthesis of 2,4 ‐diphenyl‐1,2 dihydroquinazoline and their analogues. The reactions were performed with different type of benzylamine and 2‐bromo benzophenone using ammonium acetate and characterized by 1H NMR, 13C NMR and Mass spectroscopic techniques. All the compounds were tested for MDA‐MB‐231, A549 and DU‐145 type of human cancer cell lines. Among the synthesized compounds, 4 j (4‐phenyl‐2‐(3,4,5‐trimethoxyphenyl)‐1,2‐dihydroquinazoline) and 4 e (2‐(3,4‐dichlorophenyl)‐4‐phenyl‐1,2‐dihydroquinazoline) molecules were found to possess good anticancer activity. The binding nature of these molecules was explored through docking studies.

An efficient n-Bu4NI/TBHP-catalyzed protocol for C–N bond formation via cross-dehydrogenative coupling of 1H-1,2,4-triazoles (N–H) and methylarenes (Csp3–H) has been developed under metal free conditions.

An efficient n-Bu 4 NI-catalyzed protocol for the synthesis of hemiaminal ethers by linking ethers with 1H-1,2,4-triazoles and 1H-indazoles has been developed under metal-free conditions. A series of ethers, 1H-1,2,4-triazoles and 1H-indazoles are tolerated in this method and gave the corresponding hemiaminal ethers in moderate to good yields.

An efficient AuCl3/AgSbF6‐catalysed enone synthesis from coupling of alkynes and aldehydes has been presented. The present reaction is very effective, simple and mild and has wide range of substrate scope. Both aryl (electron rich and electron deficient) and aliphatic aldehydes and terminal and internal arylalkynes participated smoothly in the reaction and provided exclusively trans product. This simple reaction can be coupled with other gold catalysed transformations which involve enones as substrates for further development.