Let R be a prime ring with center Z(R) and extended centroid C, H a non-zero generalized derivation of R and n ≥ 1 a fixed integer. In this paper we study the situations:where I is a nonzero right ideal of R.

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Let R be a prime ring with extended centroid C, I a non-zero ideal of R and n ≥ 1 a fixed integer. If R admits the generalized derivations H and G such that (H(xy)+G(yx))n= (xy ±yx) for all x,y ∈ I, then one ofthe following holds:(1) R is commutative;(2) n = 1 and H(x) = x and G(x) = ±x for all x ∈ R.Moreover, we examine the case where R is a semiprime ring. Finally, we apply the above result to non-commutative Banach algebras.

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