Introduction: A patient s death elicits various feelings arise in doctors such as impotence and guilt that could trigger physical or psychological symptoms. Despite its impact, few studies have explored anxiety and fear of death among physicians. Objective: To evaluate perceptions and responses to one s mortality among Latin American physicians treating COVID-19 patients. Methodology: This cross-sectional study utilized the Collet-Lester Modified Fear of Death Scale and the Death Anxiety Scale (DAS) to collect data from physicians in Latin America. Results: 219 doctors from Peru, Mexico, Argentina, Colombia, and Bolivia filled out the online questionnaire. Fear of death among the sample population ranged from 56.2% to 90%. Furthermore, the prevalence of "High Anxiety" was 80.8%. A statistically significant association was found between fear according to age and time of graduation (p = 0.010 and p = 0.020, respectively). No differences were found by gender, age, and country of origin or practice. Conclusion: Physicians experience feelings of helplessness and guilt upon the death of a patient and those feelings can trigger physical or psychological symptoms. For these states of fear and anxiety about death, more frequent in times of pandemic, doctors must be prepared, and institutions must provide them with the necessary means to help them overcome these difficult times.