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This study evaluated the abnormal psychomotor behavior of 924 patients, each of whom had received a psychiatric diagnosis at Boston City Hospital between 1966 and 1968. Fifteen cues to alterations in quantity and quality of psychomotor behavior were initially examined. Nine of these differentiated among the five major broad diagnostic groups (psychosis, psychoneurosis, personality disorder, acute brain disorder, chronic brain disorder). The same nine symptoms also differentiated to varying degrees among groupings of specific diagnostic entities. The significance of these results for alterations in diagnostic strategy was also discussed.