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The persistent intrusion of remote traumatic memories in people with post-traumatic stress disorder (PTSD) may contribute to the impairment of their ongoing hippocampal and prefrontal cortical functioning. In the current work, we have developed a rodent analogue of the intrusive memory phenomenon. We studied the influence of the activation of a remote traumatic memory in rats on their ability to retrieve a newly formed hippocampus-dependent memory. Adult male Sprague-Dawley rats were given inhibitory avoidance (IA) training, and then 24 h or 1, 6 or 12 months later, the same rats were trained to learn, and then remember across a 30-min delay period, the location of a hidden escape platform in the radial-arm water maze (RAWM). When IA-trained rats spent the 30-min delay period in the IA apparatus, they exhibited intact remote (1-year old) memory of the shock experience. More importantly, activation of the rats' memory of the shock experience profoundly impaired their ability to retrieve the newly formed spatial memory of the hidden platform location in the RAWM. Our finding that reactivation of a remote emotional memory exerted an intrusive effect on new spatial memory processing in rats provides a novel approach toward understanding how intrusive memories of traumatic experiences interfere with ongoing cognitive processing in people with PTSD.

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Two studies examined children's increasing ability to analyze tasks in terms of the perceptual features that affect task difficulty. Of particular interest was any understanding that perceptual confusions occur during the search for an object surrounded by objects similar in shape or color to that object. In Study 1, 32 pre-schoolers constructed arrays intended to make the search easy or difficult. They made the search difficult simply by putting many toys into the toy box. In a forced-choice situation, they indicated that task difficulty was influenced by the number of objects and the similarity in color and shape of the targets and the surrounding objects. Study 2 more thoroughly examined knowledge of color and shape confusions, using 96 children from Grades K, 1, 3, and 4, assigned to two age groups. The older children but not the younger ones showed a significant understanding of color and shape confusions. Both age groups understood that performance is affected by a person's interest level and degree of attention to the task. The results were discussed in terms of the accessibility of the children's knowledge under different conditions.