Centrins are calcium binding proteins that belong to the EF-hand superfamily with diverse biological functions. Herein we present the first systematic study that establishes the relative stability of related centrins via complementary biophysical techniques. Our results define the stepwise molecular behavior of human centrins by two-dimensional infrared (2D IR) correlation spectroscopy, the change in heat capacity and enthalpy of denaturation by differential scanning calorimetry, and the relative stability of the helical regions of centrins by circular dichroism. More importantly, 2D IR correlation spectroscopy provides unique information about the similarities and differences in dynamics between these related proteins. The thermally induced molecular behavior of human centrins can be used to predict biological target interactions that have a relative dependence on calcium affinity. This information is essential for understanding why certain isoforms may be used to rescue a phenotype and therefore also for explaining the different functions these proteins may have in vivo. Furthermore, this comparative approach can be applied to the study of recombinant therapeutic protein candidates for the treatment of disease states.

Being adapted to saline environments, halophytes are plant species that have received considerable attention due to their ability to cope with environmental stress factors, such as high concentrations of soluble salts and heavy metals. In this work, we focused on determining if the Sarcocornia neei (S. neei) plant can be considered as an indicator of heavy metal pollution in soil. This was done by analyzing the concentration of cadmium (Cd), lead (Pb), copper (Cu), and arsenic (As) in plants and soil sampled from two wetlands in the central zone of Chile: a wetland contaminated by industrial activities and a wetland protected by the Chilean government. In addition, 14 fertility parameters (pH, electrical conductivity, organic matter, nitrogen (N), phosphorus (P), potassium (K), sodium (Na), Pb, calcium (Ca), magnesium (Mg), Manganese (Mn), zinc (Zn), iron (Fe), and boron (B)) were analyzed for soil samples in both wetlands. This was done to differentiate between available elements and contamination by heavy metals. Plant and soil samples in the contaminated wetland exhibited significantly higher heavy metal concentrations in comparison to samples analyzed from the protected wetland. This indicates that the S. neei plant can be further researched as an indicator of heavy metal pollution in saline soils and possibly for phytoremediation purposes.

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The objective of this research is to analyze the redistribution of the firm power that generation plants will have with non-conventional renewable energy resources in accordance with the new regulatory framework and their participation in the maximum demand of the system in the Peruvian electricity market. For these new firm powers, the calculation method is described, which is determined by the market administrator and considered in the settlements of the valuations of power transfers, based on their participation in the maximum demand within the peak hour of the system. The peak hours of the electricity system should serve to introduce incentive mechanisms for the expansion and/or diversification of the system's generating park with RER technology that allow for virtual energy independence, reduction of carbon dioxide emissions, in addition to diversifying the matrix energetic. In December 2021, a maximum firm power of 95.36 MW wa s obtained for wind power plants and 1.67 MW for solar power plants. These powers were considered in the settlement of transfer valuations to determine the income per power; which marked less income for the rest of the conventional plants.With the application of the new regulations, the RER plants have a share in the revenue pool for firm power, resulting in a range of 29% to 43% of this amount.Of the total of the stock of income by firm power ascending to S/133,990,513, it corresponded to wind and solar power plants S/ 3,714,050, which represents 2.77%The participation in the valuation of transfers by power in the market was that wind power plants were in the range of 29% to 43%, while solar power plants did so in the order of 1% to 4% . Keywords--Wind power plants, solar power plants, firm power, energy income, rush hour