The development of the juxtaglomerular (JG) apparatus in the rat kidney was investigated at different times of postnatal life (1, 2, 3, 5, 7, 10, 15, 30 and 60 days). On the 1st day after birth, secretory granules were found in JG cells in preglomerular arterioles of juxtamedular nephrons and in interlobular arteries. JG indices are high at this stage and decrease until the 5th day, then gradually rise until the 60th day. The possible reasons for such findings are discussed. Macula densa cells start to differ as early as the 1st day after birth. They are very distinct already at 2 days and they reach typical organization by the 15th day. Extraglomerular mesangial cells are few in early postnatal life. Their number increases later on. The parallelism between nephrogenesis and development is discussed.

The juxtaglomerular apparatus and zona glomerulosa were studied histologically in rabbits during the whole pregnancy period. The granularity of the kidney juxtaglomerular cells diminishes up to 25 days at which time it reaches control values. After delivery, the juxtaglomerular index increases significantly and rises above control values. The width of the adrenal zona glomerulosa is smaller in the first half of pregnancy in comparison with controls. In the second half it rises significantly. After delivery it greatly surpasses control values.