Background: Scaling and root planing is the basic treatment modality for periodontal disease. However, mechanical treatment is limited by physical impediments and biochemical considerations. Herbal agents may be used as an adjunct to overcome limitations of mechanical therapy. Thus the aim of this research was to evaluate the effect of Aloin, (aloevera extract) as a local drug delivery (LDD). LDD was used as an adjunct to scaling and root planing (SRP). Study was aimed to compare the clinical and microbiological effect of Aloin on the levels of Porphyromonas gingivalis (P.gingivalis) and Aggregatibacter actinomycetemcomitans (A.A comitans) in the treatment of chronic generalized periodontitis (CGP). Methods: Thirty chronic generalized periodontitis patients with 90 sites were selected including both males and females in the age group of 25-55 years. Three groups were made, 30 sites in each group were assigned. Group A was treated with aloin alone as LDD. Group B was treated with SRP and Aloin, whereas Group C was treated with SRP alone. Plaque sample was collected on baseline, 15 th , 30 th day for quantitative and qualitative analysis of P.gingivalis and A.A comitans. Results: There was a statistically significant improvement in all clinical and microbiological variables, including plaque and gingival index. However greatest improvement was evident in Group B in terms of reduction in colony forming units(CFU) of P.gingivalis and A.A comitans. Conclusion: Aloin as LDD is a valuable adjunct to SRP in the treatment of chronic generalized periodontitis.

Background: Periodontal regeneration remains one of the crucial issues in the field of periodontology. Periodontal intrabony defects could be treated by surgical intervention through various alloplastic bone graft substitutes. The Food and Drug Administration approved, Novabone putty is one of the recently marketed bone graft substitutes, which has been used in the present study. This study also incorporates the placement of platelet-rich fibrin (PRF) in combination with Novabone putty. Materials and Methods: Twenty patients were included in the study and were allocated to either Group A or Group B through randomization. Group A included the placement of Novabone putty in the periodontal intrabony defects, whereas Group B included the placement of Novabone putty along with PRF. Statistical analysis of plaque index, gingival index, probing pocket depth, relative attachment level, and intraoral periapical radiographs was performed. Results: Statistical more significant difference (P < 0.05) in probing pocket depth, and relative attachment level was observed in Group B (Novabone putty and PRF) in comparison to Group A (Novabone putty). Conclusion: Evaluation of efficacy of Novabone putty along with PRF produced more favorable results in relative attachment level gain and more reduction in probing pocket depth when compared to Novabone putty alone.