Land and offshore drilling operations along the Tabasco coastline of the Gulf of Mexico notoriously present difficulties posed by the variations in pore pressure, depleted reservoirs, and, in the majority of cases, highly fractured carbonates--the last a cause of negative windows between pore pressure and fracture pressure and, thus, whole sections with complete circulation loss. It is not surprising that the drilling of these deposits takes much more time than planned. Nonproductive-time (NPT) events are particularly associated with lost circulation and/or gas influxes in high-pressure formations, well-control processes, stuck-pipe problems, deviated wells, and in some cases, wells being abandoned without the objectives having been met. To mitigate these problems, managed pressure drilling (MPD) technology, using an automated system, was implemented. The objective was to determine the limits of the operating window and to perform an equivalent circulating density (ECD) control to find a balance between the losses and gains, reducing the losses as much as possible and minimizing volume of influx from high-pressure gas intervals. This paper describes the objectives, planning, technology used, problems encountered, and lessons learned during the first application of MPD technology using an automated system in an offshore well in the Gulf of Mexico, along the Tabasco coastline.