Fournier syndrome is a severe disease that should be treated aggressively with debridement and broad-spectrum antibiotics. It usually causes loss of a large area of tissue and may spread to other areas beyond the perineum such as the abdomen, lower limbs, dorsum, chest, and retroperitoneum. The loss of the scrotum is a common condition in this pathology. Two cases of scrotum reconstruction with the fasciocutaneous flap of the inner thighs with excellent recovery, good aesthetic results, and few complications are reported.

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Implante mamário de silicone gel em posição submuscular parcial, via axilar, sem o emprego de videoendoscopia Implante mamário de silicone gel em posição submuscular parcial, via axilar, sem o emprego de videoendoscopia Silicone breast implants by axillary route with partial submuscular location without videoendoscopy assistance RESUMO Introdução: Os planos submuscular e subglandular para acomodar implantes mamários têm suas vantagens e desvantagens. Para tentar obter o melhor de cada uma destas alternativas, propõem-se os planos mistos. Objetivo: Avaliar a via axilar para a realização do plano misto na inserção do implante de silicone mamário sem videoendoscópio. Método: Estudo retrospectivo dos 27 pacientes operados pelo autor com esta técnica, no período de 2006 a 2008, foi realizado. Foram avaliados os resultados por questionário subjetivo, respondido pelas pacientes e pela revisão de seus prontuários. Resultados: As complicações e suas respectivas ocorrências foram: retrações axilares (20 casos); seromas (2 casos); contratura capsular (1 caso). As pacientes consideraram o procedimento como doloroso em apenas 29% dos casos, principalmente nas mamas. Apenas uma paciente não classificou a sua cicatriz como boa ou excelente. Todas acharam seu resultado natural e acreditam que o retalho muscular ajudou neste objetivo.

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PurposeDiabetic Retinopathy (DR) is one of the hallmark microvascular diseases secondary to diabetes. Endothelial cells and perivascular cells are key players in the pathogenesis. It has been shown that VEGF coordinates interactions between endothelial and perivascular cells. In rodent studies, VEGF injected into the eyes results in vascular retinal permeability with pericyte loss. Immunochemistry used for quantification of perivascular cells is well described for murine species but not for rabbit. The aim of the present study was to evaluate perivascular cell pattern in rabbit induced retinal permeability model.MethodsTen pigmented rabbits were induced by intravitreal injection of 500 ng rhVEGF165 into the right eye. At day 2, quantification of vascular leakage was evaluated by fluorometry in both eyes. At day 3, both eye were sampled and fixed. Anti‐ SMA and Isolectin B4 staining was performed on flat‐mounted retina. The evaluation of SMA+cells was performed along the microvasculature.ResultsArea of SMA+cells decreased with distal progression along the arterioles and venules: from 78% to 47% of coverage for arteriolar tree and 69% to 47% for venular tree, less coverage for capillary (30%). Flat‐mounted retina immunostaining analysis revealed that VEGF‐induced treated eyes displayed a remodeling and a loss of the SMA+cells coverage in comparison with left non‐induced eyes: Radial arteriole coverage decreased by 27% (A2) and 23% (A3) in VEGF‐induced eye. Radial venular coverage decreased by 22% (V2) in VEGF‐induced eye. No difference was observed on capillary vessel type with SMA immunolabelling.ConclusionsThis study showed the SMA+cells coverage pattern of retinal microvasculature in rabbit eyes and indicates that VEGF decreased SMA+cells coverage of both arteriolar and venular tree in an induced blood‐retinal barrier breakdown rabbit model.