One of the most notable problems in the Atacama desert is the low occurrence of rainfall, which leads to a shortage of surface and groundwater for different users in the region. Therefore, the task of carrying out new exploration studies of potential groundwater zones (GWPZs) is of vital importance for decision-makers in water resources. The main objective of this research is to determine potential sources of groundwater using a Multi-Criteria Decision-Making technique with remote sensors. A method of exploration using the Analytical Hierarchy Process (AHP) techniques applied to remote sensing data is provided. The AHP method allows calculating the influence of multiple factors, and along with the GIS environment, a map of groundwater exploitation potential can be produced. The results indicating GWPZs showed four classifications of groundwater potential. The distribution shows 15.02%, 23.93%, 59.80%, and 1.25% of the total area with high, moderate, low, and very low potential, respectively. The results were validated with existing wells in the study area, offering an acceptance of 86.9%. This reveals the effectiveness and accuracy of the AHP-based GIS approach as a strategy for analyzing groundwater potential in arid zones. Similarly, the tested high GWP areas are helpful for the development and management of water resources in the Caplina basin.