This paper outlines art form impacts used within Staging Time at an adult male sex offender prison in England by drawing on the voices of prisoners (aged 21–75 years), including those with undiagnosed autistic traits. We qualitatively investigate prisoner experiences from drama (n = 11), dance (n = 12), puppetry (n = 7) and singing (n = 15) projects using a theory of change approach. Based on a themed analysis of self-report data from 4 world cafés and 44 follow-up questionnaires, we conclude arts projects positively contribute to health and well-being, forming healthy relationships and prison culture. By applying a desistance theory lens, we argue arts projects provide building blocks towards crime abstinence. Whilst all arts projects improved prisoner well-being, dance had a greater propensity for increasing physical fitness. With a focus on dance impacts, our research widened to stakeholder and practitioner interviews (n = 4), alongside analysis of secondary data from dance performance audience feedback sheets (n = 48) collected by Staging Time. Audience members included prison staff, prisoners, prisoner family members and close friends and a small group of invited stakeholders. Arts projects have wider impacts on staff, other prisoners and family members.

Truncated range average torque (TRAT), peak torque (PT) and angle of peak torque (APT) in the knee extensor musculature of subjects with patellar tendon autograft anterior cruciate ligament reconstructions were compared with non-operated limbs two to four years following surgery. Twenty subjects were assessed using a Kin-Com 500H isokinetic dynamometer at three velocities for both concentric and eccentric muscle actions. Results of TRAT for the knee extensors showed average concentric and eccentric deficits of 8.48 per cent and 6.73 per cent, respectively. Deficits in PT were 8.26 per cent concentrically and 7.96 per cent eccentrically. There was no difference in the APT for each action or velocity. Despite an accelerated rehabilitation program, significant residual deficits were evident. Continued strengthening of the knee extensor muscles is recommended.

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As there is no optimal therapeutic strategy defined for women with advanced or recurrent uLMS, there is an urgent need for the discovery of novel, targeted approaches. One such area of interest is the pharmacological inhibition of the MDM2-p53 interaction with small-molecular-weight MDM2 inhibitors. Growth inhibition and cytotoxic assays were used to evaluate uLMS cell line responses to MDM2 inhibitors as single agents and in combination, qRT-PCR to assess transcriptional changes and Caspase-Glo 3/7 assay to detect apoptosis. RG7388 and HDM201 are potent, selective antagonists of the MDM2-p53 interaction that can effectively stabilise and activate p53 in a dose-dependent manner. GSK2830371, a potent and selective WIP1 phosphatase inhibitor, was shown to significantly potentiate the growth inhibitory effects of RG7388 and HDM201, and significantly increase the mRNA expression of p53 transcriptional target genes in a p53WT cell line at a concentration that has no growth inhibitory effects as a single agent. RG7388, HDM201 and GSK2830371 failed to induce apoptosis as single agents; however, a combination treatment tipped cells into apoptosis from senescence. These data present the possibility of MDM2 and WIP1 inhibitor combinations as a potential treatment option for p53WT uLMS patients that warrants further investigation.