Cryptococcal meningitis (CM) is a fungal infection most commonly seen in immunocompromised patients and rarely affecting immunocompetent patients. Cryptococcal meningitis can present with varying complications, such as disseminated disease and neurological complications that include intracranial hypertension, cerebral infarcts, and vision loss. Delayed diagnosis of CM contributes to the disease's mortality in the immunocompetent patient. We would like to present the case of a 27-year-old apparently immunocompetent woman admitted for CM with initial improvement and then neurological decline concerning for cryptococcal–postinfectious inflammatory response syndrome.

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