Purpose: To evaluate the effect of two different oral rinses on the retention and surface topography of ball attachments for implant overdentures.Materials and Methods: Thirty metal housing and the nylon cap inserts (Adin, Israel) were placed on the master block and the attachment assemblies were transferred to prosthetic blocks using the direct pickup technique. Group I had ten test samples immersed in water, Group II had ten test samples immersed in Listerine® Cool Mint®(J&J, India), Group III had ten test samples immersed in Colgate Vedshakthi oil-based herbal oral rinse (Colgate-Palmolive, India). The retention force was tested at baseline and after immersion in the respective oral rinses at 360 cycles (simulating 3 months) and 720 cycles (simulating 6 months) of clinical use, using a universal testing machine (Shimadzu, AG-X plus 50KN, Europe, GmBH) at a crosshead speed of 50 mm/min. The data was analyzed using the repeated measures ANOVA test, one-way ANOVA test, and post hoc analysis (SPSS23, Munich, Germany). The surface topography was assessed initially and subsequently after immersion in the oral rinses after 360 and 720 insertion-removal cycles using a stereomicroscope (Leica M205C, Germany).Results: At 360 cycles, the mean retention force (MRF) exhibited by Group I was higher than that of Group III and this difference was significant. The MRF of Group II was also significantly higher than Group III. At 720 cycles, the MRF exhibited by Group I was higher than that of Group II and the difference was significant. Also, the MRF of Group I was significantly higher than that of Group III, and the MRF of Group II was significantly higher than that of the Group III test samples. In Group I, the percentage loss in the MRF at the end of 360 and 720 cycles was 4.96% and 6.37%, respectively. In Group II, it was 6.82% and 9.41%, respectively, and in Group III it was 14.75% and. 16.60%, respectively.Conclusions: Colgate Vedshakti caused the highest surface topographic changes. This corroborates with the lower retention obtained, followed by Listerine® Cool Mint®, and the least changes were observed for samples immersed in water, which corroborates with the greater retention obtained in the study.