BACKGROUNDPregnancy greatly increases demand for metabolic fuels that are needed for growth and development of the foetus and its support structures. The major change in energy expenditure and in the accumulation of fat occurs at different times during pregnancy. Altered metabolic and hormonal status of the body in pregnancy leads to changes in lipid profile. An abnormal lipid profile is known to be strongly associated with atherosclerotic cardiovascular diseases and has a direct effect on endothelial dysfunction. Abnormal lipid metabolism seems important in the pathogenesis of Pregnancy Induced Hypertension (PIH). The association of serum lipid profile with gestational proteinuric hypertension is highly suggested to reflect some new diagnostic tools.This study was done to investigate the effect of pregnancy on lipid profile changes during 10 to 16 weeks of pregnancy. MATERIALS AND METHODSA total of 497 pregnant women between the age group of 17 and 43 years were enrolled after getting written informed consents from the patients. Patients with diabetes and ultrasound diagnosed foetal congenital anomaly were excluded. Data were computerised and analysed. RESULTSMean (SD) triglyceride and total cholesterol levels were 189.9 (36.85) and 209.9 (28.670) respectively. Mean (SD) of triglyceride values was visibly higher in PIH group than that of normotensive. CONCLUSIONConclusively, altered maternal serum lipid profile increases in susceptibility to the development of PIH and gestational proteinuric hypertension and other foetal diseases induced preterm birth and intrauterine growth restriction. Therefore, lipid profile estimation and monitoring should be made a part of routine investigation during antenatal period. Further studies are needed to determine if certain women are at increased risk of cardiovascular, hypertensive diseases in later life because of effects on their lipid profile during pregnancy.