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Background: The role of the cytokine interleukin-37 (IL-37) has been recognized in reversing inflammation-mediated metabolic costs. The aim was to evaluate the clinical utility of this cytokine as a diagnostic and prognostic marker in patients with type 2 diabetes (T2D). Methods: We included 170 older (median: 66 years) individuals with T2D (females: 95) and classified as primary care attenders to assess the association of factors that describe patients with plasma IL-37 levels (expressed as quartiles) using multinomial regression models. We determined the diagnostic ability of IL-37 cut-offs to identify diabetes-related complications or patient subgroups by using Receiver Operating Characteristic analysis (c-statistics). Results: Frailty status was shown to have a suppressive effect on IL-37 circulating levels and a major modifying effect on associations of metabolic and inflammatory factors with IL-37, including the effects of treatments. Situations in which IL-37 reached a clinically significant discriminating ability included the model of IL-37 and C-Reactive Protein in differentiating among diabetic patients with low–normal/high BMI ((<25/≥25 kg/m2), and the model of IL-37 and Thyroid Stimulating Hormone in discriminating between women with/without metabolic syndrome. Conclusions: The study has revealed limitations in using classical approaches in determining the diagnostic and prognostic utility of the cytokine IL-37 in patients with T2D and lain a foundation for new methodology approaches.

Tsunamis are a perilous natural phenomenon endangering growing coastal populations and tourists in many seaside resorts. Failures in responding to recent tsunami events stresses the importance of further research in building a robust tsunami warning system, especially in the “last mile” component. The lack of detail, unification and standardisation in information processing and decision support hampers wider implementation of reusable information technology solutions among local authorities and officials. In this paper, the architecture of a tsunami emergency solution is introduced. The aim of the research is to present a tsunami emergency solution for local authorities and officials responsible for preparing tsunami response and evacuation plans. The solution is based on a combination of machine learning techniques and agent-based modelling, enabling analysis of both real and simulated datasets. The solution is designed and developed based on the principles of enterprise architecture development. The data exploration follows the practices for data mining and big data analyses. The architecture of the solution is depicted using the standardised notation and includes components that can be exploited by responsible local authorities to test various tsunami impact scenarios and prepare plans for appropriate response measures.

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