BACKGROUND: Perceived stress scale is the psychological instrument used for measuring the perception of stress. It is a measure of degree to which situations in one’s life are appraised as stressful. The Buteyko Method incorporates reduced-volume breathing as its fundamental technique, which is done by sitting in an erect posture and relaxing the muscles of respiration until one feels a slight lack of air. This sensation of slight breathlessness is then maintained by a combination of relaxation of breathing muscles, erect posture, and a little tension of the abdomen. This study concentrates on effect of Buteyko breathing technique on stress in Physiotherapy students. AIM: To study the effect of buteyko breathing technique on stress in physiotherapy students. METHODOLOGY: The design of study is experimental and type of sampling is purposive convenient sampling. The sample size taken was 40 and the place of study was physiotherapy OPD. RESULTS: The results were obtained using perceived stress scale on the basis of pre and post data collected. Statistical analysis shows the positive effectiveness of buteyko breathing technique on stress in physiotherapy students. CONCLUSIONS: The stress can be reduced significantly with buteyko breathing technique. Keywords: Stress, Buteyko Breathing Technique, Perceived Stress Scale, Physiotherapy students.