Background: Uterine fibroids are benign tumors arising from smooth muscle cells of myometrium. This study was conducted in rural women belonging to poor socio-economic class and primary school dropouts to find out clinical presentation, prevalence of uterine fibroids, their knowledge about health services and to develop modalities to improve awareness and early reporting to prevent morbidity and improve quality of life.Methods: Women ranging from 26-55 years age attending Gynecology OPD of SSSMCRI for abdominopelvic mass, pain, menstrual abnormalities over a period of 3 years were registered for the study. Socio-demographic profile, detailed menstrual history, reason for attending hospital and previous treatment taken prior to the hospital visit were recorded. Women with pregnancy with fibroids and fibroids detected by ultra-sonogram less than 12 weeks were excluded from the study. Clinical, local and ultra-sonographic examination was done for the morphology of the fibroids. Comparison was done with histological picture for accuracy in clinical and sonographic diagnosis.Results: 362 women who presented with uterine fibroids, menorrhagia or with abdomino pelvic mass were registered for this study. Of 136 patients who had uterine fibroids 66% had menorrhagia with severe anemia, 23% needed blood transfusion, 17 were nulliparous women. Menorrhagia was the commonest menstrual pattern seen in 58.8% women. Asymptomatic fibroids with huge abdomino pelvic mass was seen in 46 women (33%). The size was 12-28 weeks. The mean age was 46 years. Abdominal hysterectomy was done in 88 women, and 3 in-situ hysterectomies (91 cases) (67%), polypectomy in 16 and myomectomy in 22 nulliparous women. Laparotomy for torsion sub-serous fibroids was done in 7.Conclusions: Further research is needed to find out biological factors causing fibroids including diet, stress, environmental and racial influences. Routine screening, early detection, increase awareness by early reporting to the hospital will reduces morbidity and improves quality of life socioeconomically.

Introduction: Hemolytic anaemias are a group of disorders that cause significant morbidity in children. Method: A cross sectional study was conducted at NRI Medical College for a period of 1 year. All cases of newly diagnosed and old cases of hemolytic anaemia on follow up were included. Results: The study showed beta thalassemia as the most common hemolytic anaemia; followed by malaria, sickle beta thalassemia, thalassemia intermedia, beta thalassemia minor, Sickle cell disease, sickle cell trait, auto immune hemolytic anaemia, and hereditary spherocytosis. The mean hemoglobin at presentation was 5.39 gm/dl. Anthropometric measurements in 32 cases of congenital hemolytic anaemias revealed height < 3 rd centile in 9 cases. Weight less than 3 rd centile was seen in 11 cases. 13 children had hemolytic facies. Massive splenomegaly causing discomfort, gall stones, heart failure were seen in 2 cases each. In thalassemia major, 10 cases required frequent transfusions, [10-12 per year]. 9 came for less frequent transfusions [6 per year]. Sickle thalassemia, thalassemia intermedia, required one transfusion every 1-2 years. Occasional transfusions were given in sickle cell anaemia, hereditary spherocytosis. Serum ferritin levels varied between 220-1427. Conclusion: Hemoglobin electrophoresis remains the main investigation of choice in diagnosis of hemolytic anaemia. Thalassemia major is the most severe among other hemolytic anaemias encountered in this series. The study emphasizes the need to improve awareness regarding hemoglobinopathies among population, prenatal screening, blood transfusion policies, chelation policies to prevent complications in transfusion dependent patients.

Thyroglossal duct cyst is a congenital malformation occurring due to incomplete closure of the thyroglossal duct. The infrequency with which it is encountered in thyroid makes it a formidable diagnostic challenge. Authors report this case because of the rarity of intrathyroid location of thyroglossal cyst.

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Paliperidone is a BCS-II drug. It means paliperidone is poorly water soluble and hence shows problem in absorption as well as permeation through GIT which together contributes for its lower oral bioavailability. Paliperidone as drug, oil oleic acid, surfactant labrasol and co surfactant labrafil m 1944 were taken and formulation were done. From the emulsification time study as the concentration of Smix increases emulsification time decreases. Further emulsification time study I found that F3 has the lowest emulsification time. From the dissolution study it was observed that Q30 is above 85% obtained for formulation F3 and F6 that is 93.75 & 91.25. This can be due to the higher concentration of Smix present in formulation F3 & F6 since mean cumulative % drug release at 30min (Q30) is highest for F3 formulation and it was selected for optimized formulation. As in the DSC study thecrystalline property of Paliperidone is lost and it becomes amorphous. In the FT-IR study there is no significance sifting of characteristic peak. Hence there is no incompatibility between drug and excipient.