Introduction: Adolescence is a period of transition from complete dependence to relative independence stage. Onset of menarche brings major physiological changes which is often associated with problems of irregular menstruation, excessive bleeding and dysmenorrhea. Objectives: Study aimed to assess the effectiveness of comprehensive nursing intervention in improving adolescent girls' knowledge and practices regarding dysmenorrhea. Methods: Study design is quasi experimental non randomized pre-test and post-test control group, 60 adolescent girls (30 in control and 30 in experimental group) from selected schools of district Sirmour, H.P. Data was collected by self-administered questionnaire and self-report practice check list. Results: In experimental group, Mean ± SD of knowledge score was 8.27±2.864 for pre-test and 29.57±2.956 and 13.10±2.482 respectively for two post-test, whereas in control group, it was 8.43±2.909 for pretest and for post-test it was 8.50±2.921 and 8.27±2.924 respectively. Self-report practice score for pre-test and two post-tests were 3.63±1.866, 5.67±1.322 and 8.70±1.643 in experimental group. While in control group practice scores for pre-test and two post-tests were 4.20±2.058, 4.20±2.024 and 4.33±2.073. Repeated ANOVA was used to find out the relationship between pre-test, post-test 1 and post-test 2 at p ≤ 0.05 level of significance. Chi test was used to find out the association at p≤ 0.05 level of significance. There was no association found between Conclusion: The result of the study suggested that there was improvement in the knowledge and practice of adolescent girls after the implementation of comprehensive nursing intervention.
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