Compounds V and VI were demonstrated viral inhibition towards Human cytomegalovirus, whereas cyclopropylquinoline derivative IV towards Rift Valley fever virus and Tacaribe virus. Additionally, cyclopropylquinoline derivative IV has displayed very good cytotoxicity against colon, breast and leukemia cell lines in vitro.

Our research identified a novel 5,6-dimethoxyindan-1-one analog (compound 7), as a potent antiviral agent for vaccinia virus, and heterocyclic chalcone analog (compound 9) as a broad spectrum antiviral agent.

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A series of new Schiff bases of 4-(methylthio)benzaldehyde derivatives 3(a-i) were synthesized by the reaction of 4-(methylthio)benzaldehyde with various amines 2(a-i). Newly synthesized compounds were characterized by elemental analyses, UV-visible, FT-IR, Mass and 1 H NMR spectral studies. All compounds were evaluated for their in vitro antibacterial activity against clinically isolated strains i.e., E. Coli, P. Fluorescence, M. Luteus and B. Subtilis. These compounds were screened for their antioxidant activity by 2,2-diphenyl-1-picryl-hydrazyl (DPPH • ) and ferrous ion chelating assay (Fe 2+ ) methods. The cytotoxicity assay was performed by tryphan blue dye exclusion method. Compounds 3g, 3h and 3i exhibited good antibacterial activity when compared with other compounds in the series against tested pathogenic bacterial strains. All the compounds showed antioxidant activity, where compound 3b was the best radical scavenger and Fe 2+ ion scavenger. These findings showed that the Schiff bases of 4-(methylthio)benzaldehyde derivatives possess antioxidant activity with different mechanism of actions towards the different free radicals tested. Among these derivatives, 3b and 3h had the strongest activity against human peripheral lymphocytes.

A variety of chalcone derivatives were synthesized via aldol condensation of diverse aldehydes with acyclic and cyclic ketones, under mild reaction conditions. Reaction yields of pure products fluctuated from 48 % to 81 %. An unusually wide range of substrates including quinolines, thiophenes, pyridines, and fluorinated compounds were synthesized for this study. Full characterization data, along with in vitro antimicrobial activity for all adducts, are herein reported. Whole cell growth inhibition assays against staphylococcus aureus, escherichia coli, klebsiella pneumonia, acinetobacter baumannii, pseudomonas aeruginosa, candida albicans and cryptococcus neoformans var. grubii were performed employing all synthesized compounds (3a-m).