Despite great efforts in treatments of cardiovascular diseases, the field requires innovative strategies because of high rates of morbidity, mortality and disability, indicating evident deficits in predictive vascular diagnosis and individualized treatment approaches. Talking about the vascular system, currently, physicians are not provided with integrated medical approaches to diagnose and treat vascular diseases. Only an individual global approach to the analysis of all segments in the vascular system of a patient allows finding the optimal way for vascular disease treatment. As for the existing methodology, there is a dominance of static methods such as X-ray contrast angiography and magnetic resonance imaging in angiomode. Taking into account the world experience, this article deals with innovative strategies, aiming at predictive diagnosis in vascular system, personalization of the biomedical treatment approaches, and targeted prevention of individual patient cohorts. Clinical examples illustrate the advances in corresponding healthcare sectors. Recommendations are provided to promote the field.

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Practical medicine requires new research to better understand the processes of blood flow through the vascular system. In particular, the processes of blood movement in capillaries, when their diameter is smaller than the diameter of erythrocytes, are of interest. It is believed that the center of mass of the erythrocyte lies on the midline of the capillary. While in the arterioles, the erythrocyte releases nutrients, so its mass decreases. When moving in the venule, the mass of the erythrocyte increases because it receives spent substances from the tissue space. The vascular wall of the capillary and its midline are modeled using the equation of the parabola, which makes it possible to calculate within the specified limits the length of the wall and the midline. The movement of an erythrocyte is described by the Meshchersky equation for bodies with variable mass. The proposed article is devoted to the construction of static models of capillaries in the norm and a dynamic model of movement in the capillary of an erythrocyte with variable mass.

Some important aspects in evidence-based medicine have not been included in basic and applied research. The current level of examination of the cardiovascular system requires new analytical approaches for the prevention of cardiovascular diseases, insults and infarctions in people of different age, and diminishing of disability and mortality of vascular critical states.

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