The aim: To study and analyze the dynamics, age, and regional characteristics of the incidence of urogenital mycoplasmosis in Ukraine during 2014-2019 and to substantiatemedical and organizational approaches to improving the prevention of urogenital mycoplasmosis among women. Materials and methods: To study the dynamics, age, and regional characteristics of the prevalence and incidence of urogenital mycoplasmosis in women, reference and statistical materials of the State Statistics Service of Ukraine, reference materials and data from reporting forms No. 9, 34, 35 of the Center for Medical Statistics for 2014-2019 were used. Results: The current trends in the dynamics of the incidence of urogenital mycoplasmosis among female population in Ukraine during 2015-2019 are determined, its age features are established, the regional distribution of administrative territories of Ukraine according to the incidence of urogenital mycoplasmosis is substantiated, medical and organizational approaches to improving menopause among women are substantiated. Conclusions: The results of the study showed that although urogenital mycoplasmosis is most often diagnosed among women of childbearing age, the risk of infection exists for women of all ages, which indicates the urgency of providing effective measures to prevent it.A wide range of regional indicators of incidence of urogenital mycoplasmosis in women was established: from 0.9 per 100 thousand female population in the Zakarpattia region to 230.9 per 100 thousand in Kharkiv region, with in excess of the average Ukrainian indicator in a number of oblasts by1.8-3.2 times. There is a tendency towards redistribution during 2010-2018 of the age structure of patients with urogenital mycoplasmosis: against the background of a slight decrease in the proportion of age groups from 0 to 14, 15-19, 20-29 years there is an increase in the proportion of other age groups, but the first rank place, as in previous years, is retained by the age group of 20-29 years: 48.4% in 2010, 39.1% in 2018). A statistically reliable correlation connection between age and the level of incidence of urogenital mycoplasmosis among women is not revealed.