Background Association of work schedule in industrial workers with the progression of metabolic syndrome, insulin resistance, and serum adipokine concentrations is incompletely explored. Objective To determine the association of work schedule with the progression of metabolic syndrome, insulin resistance, and adipokine concentrations in industrial workers. Methods In a cross-sectional study design of industrial workers we compared metabolic syndrome, insulin resistance, and adipokines concentration between workers in the day shift (n = 52), rotational shift (n = 21), and night shift (n = 15). The international Diabetes Federation criteria were used to diagnose metabolic syndrome. We used a homeostatic model assessment of insulin resistance (HOMA-IR). Serum insulin, leptin, and adiponectin concentrations were measured using enzyme-linked immunosorbent assays. Serum glucose, triglyceride, and high-density lipoprotein cholesterol (HDL-C) concentrations were monitored using Prietest clinical chemistry reagents. Results The proportional difference in metabolic syndrome (0.31, 95% confidence interval [CI] 0.036–0.587, P = 0.026), median difference of leptin (0.61, 95% CI 0.186–1.034, P = 0.005), and leptin-to-adiponectin ratio (LAR; 0.45, 95% CI 0.235–0.665, P < 0.001) was significantly higher, and serum adiponectin was lower (–2.00, 95% CI −4.197 to 0.197, P = 0.07) in the night-shift workers compared with that of day-shift workers. Among rotational-shift workers, the proportional difference between metabolic syndrome (0.14, 95% CI −0.098 to 0.378, P = 0.25), median difference of leptin (0.25, 95% CI −0.124 to 0.624, P = 0.19), and LAR (0.09, 95% CI −0.099 to 0.279, P = 0.35) was higher, and serum adiponectin concentration was lower (−0.73, 95% CI −2.660 to 1.208, P = 0.46) compared with that of day-shift workers; however, the altered differences were not significant. We observed a higher proportion of difference in HOMA-IR in shift workers (night and rotation) than in day-shift workers. Conclusion Night-shift workers are vulnerable to a higher risk of metabolic syndrome, HOMA-IR, and adipokine changes.

Background: Most of the studies were reported serum adipokines with the presence of metabolic syndrome (MetS) in population-based studies. Objective: The present study assessed the levels of serum adipokines, i.e., leptin, adiponectin, leptin:adiponectin ratio (LAR), and adiponectin:leptin ratio (ALR), and the development of MetS among industrial workers. Methods: Eighty-eight workers were recruited in the study. MetS was diagnosed using the definition of the International Diabetes Federation. Serum leptin and adiponectin levels were done using enzyme linked immunosorbent assay methods. LAR and ALR values were calculated using the serum leptin and adiponectin. The data was analyzed using statistical package for the social sciences software. Mann-Whitney U test was used to find out the differences of adipokines among workers with or without MetS. Kruskal-Wallis test was used to find out the effect of the number of metabolic components (0, 1, 2, 3, and >4) on serum adipokines among workers. Results: 37.5% of workers had MetS. The levels of serum leptin (p < 0.01) and LAR (p < 0.01) were significantly increased and serum adiponectin (p = 0.104) and ALR (p < 0.01) were decreased in workers with the presence of MetS. The effect of the number of metabolic components was demonstrated a significant increase of serum leptin (p = 0.018) and LAR (p = 0.026) and significant decrease of ALR (p = 0.046). Conclusion:The levels of serum leptin and LAR were increased and adiponectin and ALR were decreased in workers with the presence of MetS and the number of metabolic components. The data of the present study support the role of adipokines and development of MetS. It could be used as specific indicators for the diagnosis and management of MetS.

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