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In preclinical studies, 5-imino-2,2,4,4-tetrakis (trifluoromethyl) Departments of Neurological Research, Neuropsychiatric Examining Service, and Therapeutics, Veterans Adminiotration Outpatient ClinicThe structure of 5-imino-2,2.,4,4-tetrakis (triRuoromethyl) imidazolidine (EXP 338)" is shown in Fig. l,1 Preclinical studies revealed that this preparation is capable of reducing abnormal neural activity by its effect on polysynaptic reRex arcs and to a lesser degree upon monosynaptic circuits in experimental animals. No evidence of peripheral interference with neuromuscular transmission was found.8 Toxicology studies revealed no toxicity which would preclude clinical trial. Subsequently it was given to about 20 patients with neurologic diseases for 1 to 60 days without any apparent alterations in urine or blood. 2 Studies in mice with 14C-Iabeled drug indicated a half-life of 8 hours and that the drug was rapidly absorbed and uniformly distributed. 9 Adverse effects of drowsiness, disorientation, ataxia, and convulsions had followed single doses of 50 to 100 mg. of the test drug given orally.2Received for publication Dec. 19, 1967. Accepted for publication April 9, 1968. ·IND, DuPont, Wilmington. Del. 448A quantitative, non blind evaluation of oral EXP 338 was carried out on 15 pa-

Abstract. In the present study, the availability of smoking cessation programs (SCP) was surveyed in the same randomly selected USA hospitals in 2000 and 2012. A total of 102 USA hospitals were randomly selected for this survey. Each hospital website was searched for the topic of smoking cessation. In the second phase of the survey, the main switchboard number of each hospital was anonymously telephoned and the 'stop smoking clinic' was requested. The phone survey results showed that the percentage of hospital switchboard calls that were connected to a SCP remained identical at 47% in 2000 and 2012. The results for the internet availability of SCP on hospital websites improved from 30% in 2000 to 47% in 2012. There were more hospitals that added additional SCP information (27%) compared with those that removed SCP information (15%) by 2012. Among the 57% of hospitals that showed no change in internet SCP information, 22% remained positive for such information while 35% remained negative. The phone survey of hospitals showed that 47% of USA hospitals were able to connect a caller to a SCP in the years 2000 and 2012. While there was no reduction over the 12 years, there was no increase in the percentage of hospital switchboards that connected to a SCP. Availability of SCP information on hospital web sites improved to a limited extent; increasing from 30% of sites in 2000 to 47% in 2012. Providing SCP on a hospital website is easy and free, for example adding a link to QuitNet or QuitLink. The present study adds to information gathered 12 years earlier, and is unusual in being able to provide follow-up data on the same set of hospitals studied previously.