This article presents 4 new cases of basal cell carcinoma of the vulva and a review of 61 previously reported cases. The average age is 64.8 years. The usual lesion is a mass or lump associated with a long‐standing history of pruritus. Ulceration and/or bleeding are not uncommon. The average duration of symptoms is 4.8 years. Complete local excision is curative, although the recurrence rate is high and probably exceeds 20 percent. Careful follow‐up is advised. Although radical surgery is not indicated, wide excision in selected cases may be considered, especially if careful follow‐up may be a problem. There is a high (20 percent) association with other primary malignancies.

Purpose-To determine whether signs and symptoms of ocular surface disease improve after placement of a self-retained, cryopreserved amniotic membrane (CAM) in patients with Sjögren syndrome (SS). Methods-The medical records of SS patients who received a self-retained CAM implant (Prokera or Prokera Slim; TissueTech Inc, Doral, FL) for the treatment of ocular surface disease between August 2012 and August 2016 at a single, large academic institution were reviewed retrospectively. Visual acuity, results of slit-lamp examination of the cornea and conjunctiva, and dry eye symptoms, were evaluated before and after CAM insertion.Results-A total of 6 eyes of 6 patients (all female; mean age, 62.5 ± 13.0 years [range, 49-86 years]) were included. All patients were on topical medications at the time of the study and had signs of ocular surface dryness. There were reductions in corneal and/or conjunctival staining in 5 eyes (83%) after the CAM dissolved. All patients who completed therapy (5/5) experienced a relapse in their signs and symptoms within 1 month of removal of the CAM, with an average time to relapse of 24.6 days. Mean follow-up time was 54.5 days. Foreign body sensation and blurred vision were the most common complaints associated with the CAM implant.

When rats, mice, hamsters, and guinea pigs were caused to inhale either human or bovine tubercle bacilli as separate cells in fine droplet nuclei, the number of initial tubercles equalled approximately the number of bacilli calculated to have been inhaled. Moreover, the initial tubercles in the eight host-parasite combinations developed to macroscopic size within 4 weeks, apparently at a highly uniform rate, but thereafter the rate and pattern of tubercle formation varied widely (1). It seems probable, therefore, that these species do not differ in their "native" or inherent resistance to the bacilli of tuberculosis. Instead, they differ in their capacity to acquire resistance to these organisms.Additional evidence to support this hypothesis is provided by the present study, which traces the sequence of tissue changes through the homogeneous stage of the response to infection in the eight host-parasite combinations to its transformation into the later, heterogeneous phases of the disease. This study demonstrates that the rate and pattern of tubercle formation in all eight hostparasite combinations are, indeed, hfghlyuniform for a time, and correspond closely to the initial stages of tubercle formation in rabbits infected by bovine tubercle bacilli (2, 3). Material and MethodsThe animals used in these experiments, and their weights, were: albino mice, 15 to 20 gln.; Syrian hamsters, 80 to I00 gin.; Long-Evans rats, 150 to 200 gin.; and short haired guinea pigs, 500 to 800 gin. Commercial diets were fed.Infections were induced by means of the Wells' apparatus and techniques, which fulfill the postulates that govern quantitative control of droplet nuclei infection (4-7). Under these conditions the number of initial tubercles has approximated liters of aerosol inhaled times