Quality of life is an essential aspect of physical and mental health, which can be affected by burnout. There is evidence that shows the effects of psychological disorders such as professional exhaustion associated with poor quality of life as a reduction of motivation and professional achievement. Besides, burnout influences social, physical, cognitive and professional aspects. Therefore, the objective of this study was to analyze the participants' vulnerability to burnout and their quality of life levels. Also, to compare the quality of life of the individuals most vulnerable to this syndrome with the rest of the sample of lower vulnerability. The present study included 52 workers between doctors and teachers. Data collection consisted of the Sociodemographic Inventory, Whoqol-Bref, and Maslach Burnout Inventory response. The results showed that 19.2% of the total sample had high levels of burnout and these same participants also obtained lower scores in all domains of quality of life compared to the other participants. These problems can be seen as a social issue because their consequences, such as the loss of quality of work and even harmful effects on the health system and education extend and affect other people who are directly related to those professionals vulnerable to the syndrome.