The synergistic use of remote sensing and unsupervised machine learning has emerged as a potential tool for addressing a variety of environmental monitoring applications, such as detecting disaster-affected areas and deforestation. This paper proposes a new machine-intelligent approach to detecting and characterizing spatio-temporal changes on the Earth’s surface by using remote sensing data and unsupervised learning. Our framework was designed to be fully automatic by integrating unsupervised anomaly detection models, remote sensing image series, and open data extracted from the Google Earth Engine platform. The methodology was evaluated by taking both simulated and real-world environmental data acquired from several imaging sensors, including Landsat-8 OLI, Sentinel-2 MSI, and Terra MODIS. The experimental results were measured with the kappa and F1-score metrics, and they indicated an assertiveness level of 0.85 for the change detection task, demonstrating the accuracy and robustness of the proposed approach when addressing distinct environmental monitoring applications, including the detection of disaster-affected areas and deforestation mapping.