Stevens-Johnsons syndrome and toxic epidermal necrolysis are the most severe cutaneous adverse reactions to medications. These are characterized by the detachment of dead epidermis and the erosion of mucus membrane. Lamotrigine is an antiepileptic drug used in the management of various forms of seizures. Lamotrigine is also useful in preventing the depressive phase of manic depressive disorder. We present a case of toxic epidermal necrolysis induced by Lamotrigine to increase the awareness to this life threatening adverse drug reaction to Lamotrigine, as Steven Johnson syndrome and Toxic epidermal necrolysis have a significant impact on public health in view of their high mortality and morbidity.