Diabetes mellitus is the disease of concern in almost all part of the world including India and it clinical condition characterized by chronic hyperglycaemia. Neutrophils lymphocyte ratio is a relatively newer parameter that has been recently considered as alternate to assess the underlying inflammation and it can be easily determined with the help of complete blood count report. The aim of this study was to observe the status of NLR ratio in newly diagnosed type -2 diabetes mellitus patients and healthy individuals in Indian population. A comparative cross- sectional study was conducted in subjects between 19-60 years of age. A total of 216 age matched type-2 diabetes mellitus patients and 216 healthy individuals were selected for the study. All subjects were investigated for complete blood count, (CBC), Fasting and Postprandial blood sugar, and Glycated Hemoglobin (HbA1c) in hospitals lab services. This study has been conducted in the Department of Physiology in collaboration with Department of Medicine, and Hospital Lab Services after having clearance from the institutional ethical committee at Maharaja Suheldev Autonomous State Medical College and Maharshi Balark Hospital bahraich, uttar Pradesh.

Introduction: Stress and sedentary lifestyles frequently result in chronic health issues such as diabetes; a metabolic disorder that impacts the neural system as a result of changes in multiple metabolic pathways. Long-term diabetes mellitus causes neuropathy, which affects the autonomic nervous system. The study was initiated based on indications that sweat glands innervated by the autonomic nervous system would be impacted in individuals with type 2 diabetes mellitus who also had neuropathy symptoms. The purpose of this study was to examine galvanic skin resistance (GSR) in patients with type 2 diabetes mellitus and healthy individuals. Material & Methods: A total of 60 subjects between the ages of 25- 60 years were included in the study. 60 healthy individuals in the same age group with no history of diabetes mellitus and neuropathy served as controls, while/participants with diabetes mellitus and a history of neuropathic symptoms served as cases. Galvanic skin resistance (GSR) was recorded using Physio-Pac 4 channel digital polygraph at the department of medicine. All recordings were made between 10:00 a.m. and 12:00 p.m. in the supine position at room temperature.Result: Basal Galvanic skin resistance was higher in the diabetic patients. There was significant decrease in GSR with posture change.

Introduction: Stress and sedentary lifestyles frequently result in chronic health issues such as diabetes; a metabolic disorder that impacts the neural system as a result of changes in multiple metabolic pathways. Long-term diabetes mellitus causes neuropathy, which affects the autonomic nervous system. The study was initiated based on indications that sweat glands innervated by the autonomic nervous system would be impacted in individuals with type 2 diabetes mellitus who also had neuropathy symptoms. The purpose of this study was to examine galvanic skin resistance (GSR) in patients with type 2 diabetes mellitus and healthy individuals. Material & Methods: A total of 60 subjects between the ages of 25- 60 years were included in the study. 60 healthy individuals in the same age group with no history of diabetes mellitus and neuropathy served as controls, while/participants with diabetes mellitus and a history of neuropathic symptoms served as cases. Galvanic skin resistance (GSR) was recorded using Physio-Pac 4 channel digital polygraph at the department of medicine. All recordings were made between 10:00 a.m. and 12:00 p.m. in the supine position at room temperature. Result: Basal Galvanic skin resistance was higher in the diabetic patients.

Aim: Lactate dehydrogenase (LDH) is an enzyme that acts as a catalyst in the conversion of lactate to pyruvate which is abundantly found in liver, kidney, heart and muscles. Previous studies have all shown a strong positive correlation between muscle fatigue and increased serum LDH levels with type 2 diabetes mellitus but no study has actually assessed the same for prediabetes. The basic objective of this study, thus, is to find out the correlation between muscle fatigue and serum LDH levels in prediabetic individuals. Methods: A cross-sectional study was conducted in adults between 24–60 years old who were classified as prediabetic individuals as per norms established by American Diabetes Association. A total of 100 prediabetic individuals were selected for the study. Fatigability was calculated as a function of work done by the pleximeter finger of the dominant hand using Mosso’s ergograph. The study was conducted at Rajarshi Dashrath Autonomous State Medical College, Ayodhya. Results: Out of 100 prediabetic participants, 50% were males with a mean age of 44.14 ± 10.91 years and remaining 50% were females with a mean age of 41.12 ± 11.5 years. Overall, the average work done by the participants was 2.9 ± 1.2 weight lifted•total distance moved (kg•m) with an average serum LDH level of 323.84 ± 26.82 unit/litre (U/L). Conclusions: This study aimed at assessing the correlation between muscle fatigue and serum LDH levels in prediabetic individuals so that further work can be initiated to improve the quality of life in prediabetics that maybe drastically hampered due to easy fatigability in prediabetic individuals.