IMPORTANCE Despite the high prevalence and potential outcomes of major depressive disorder, whether and how patients will respond to antidepressant medications is not easily predicted. OBJECTIVE To identify the extent to which a machine learning approach, using gradient-boosted decision trees, can predict acute improvement for individual depressive symptoms with antidepressants based on pretreatment symptom scores and electroencephalographic (EEG) measures. DESIGN, SETTING, AND PARTICIPANTS This prognostic study analyzed data collected as part of the International Study to Predict Optimized Treatment in Depression, a randomized, prospective open-label trial to identify clinically useful predictors and moderators of response to commonly used first-line antidepressant medications. Data collection was conducted at 20 sites spanning 5 countries and including 518 adult outpatients (18-65 years of age) from primary care or specialty care practices who received a diagnosis of current major depressive disorder between December 1, 2008, and September 30, 2013. Patients were antidepressant medication naive or willing to undergo a 1-week washout period of any nonprotocol antidepressant medication. Statistical analysis was conducted from January 5 to June 30, 2019. EXPOSURES Participants with major depressive disorder were randomized in a 1:1:1 ratio to undergo 8 weeks of treatment with escitalopram oxalate (n = 162), sertraline hydrochloride (n = 176), or extended-release venlafaxine hydrochloride (n = 180). MAIN OUTCOMES AND MEASURES The primary objective was to predict improvement in individual symptoms, defined as the difference in score for each of the symptoms on the 21-item Hamilton Rating Scale for Depression from baseline to week 8, evaluated using the C index. RESULTS The resulting data set contained 518 patients (274 women; mean [SD] age, 39.0 [12.6] years; mean [SD] 21-item Hamilton Rating Scale for Depression score improvement, 13.0 [7.0]). With the use of 5-fold cross-validation for evaluation, the machine learning model achieved C index scores of 0.8 or higher on 12 of 21 clinician-rated symptoms, with the highest C index score of 0.963 (95% CI, 0.939-1.000) for loss of insight. The importance of any single EEG feature was higher than 5% for prediction of 7 symptoms, with the most important EEG features being the absolute delta band power at the occipital electrode sites (O1, 18.8%; Oz, 6.7%) for loss of insight. Over and above the use of baseline symptom scores alone, the use of both EEG and baseline symptom features was associated with a significant increase in the C index for improvement in 4 symptoms: loss of insight (continued) Key Points Question Can machine learning models predict improvement of various depressive symptoms with antidepressant treatment based on pretreatment symptom scores and electroencephalographic measures? Findings In this prognostic study, using the machine learning approach of gradient-boosted decision trees, the ElecTreeScore algorithm could reliably distinguish the patients who r...

Audio codecs based on discretized neural autoencoders have recently been developed and shown to provide significantly higher compression levels for comparable quality speech output. However, these models are tightly coupled with speech content, and produce unintended outputs in noisy conditions. Based on VQ-VAE autoencoders with WaveRNN decoders, we develop compressor-enhancer encoders and accompanying decoders, and show that they operate well in noisy conditions. We also observe that a compressor-enhancer model performs better on clean speech inputs than a compressor model trained only on clean speech.

In this paper, the authors present a novel method of prosthetic control for amputees who are missing a subset of their digits. The core of the system is a personalized set of basic configurations of the human hand to facilitate given tasks, referred to as use-patterns. In the concept, the system first senses the positions of the remaining, healthy digits using resistive flex sensors mounted onto a glove. Then, an algorithm using a Zscore metric compares the flex sensor readings to a large set of training data to determine which of several use-patterns the current situation corresponds to. A control system can then move a bionic digit into the intended position corresponding to the usepattern detected, completing the grip. MATLAB simulations were run to determine the accuracy of this concept on five exemplary use-patterns. The success rate with one amputated digit was 96.5% and the success rate with two amputated digits was 92.5%. This demonstrates the feasibility of a simple, intuitive, and lowcost prosthetic control system based on this premise that could deliver even higher success rates when personalized with selflearning algorithms.

Audio codecs based on discretized neural autoencoders have recently been developed and shown to provide significantly higher compression levels for comparable quality speech output. However, these models are tightly coupled with speech content, and produce unintended outputs in noisy conditions. Based on VQ-VAE autoencoders with WaveRNN decoders, we develop compressor-enhancer encoders and accompanying decoders, and show that they operate well in noisy conditions. We also observe that a compressor-enhancer model performs better on clean speech inputs than a compressor model trained only on clean speech.

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