Dengue is a Flavivirus, affecting about 100 million people annually and mainly in the tropical and subtropical countries. Neonatal dengue is uncommon and usually by vertical transmission or, in the postnatal period, by horizontal transmission. We describe the clinical profile, management and outcome of neonates with dengue infection. Ten patients were prospectively recruited from August to November 2019 during dengue epidemic season at Niloufer Hospital, Hyderabad, India. Four babies had vertical mode of transmission while 6 had horizontal mode of transmission. All babies were positive for Ns1 antigen and IgM dengue serology, confirming dengue infection. Fever, flushing and thrombocytopenia were observed in all the babies while 2 babies had hypotension requiring inotropes. Oxygen supplementation was required in 8 babies. There was no recorded mortality. We conclude that neonatal dengue should be considered as a differential diagnosis in a neonate with sepsis and thrombocytopenia especially in endemic regions. Judicious use of fluids (avoid excessive) and inotropes (dopamine) form the cornerstone of dengue management in neonates.

No abstract

Seizures are the most common neurologic disorder of childhood. A study was undertaken to find the correlation between serum Calcium and Magnesium levels and seizure disorders in pediatric age.It was a prospective case control time bound study, conducted in the department of paediatrics, Gandhi Medical College, Secunderabad. Study protocol was approved by the institutional ethics committee. Informed written consent was taken from the parents of the participants. Children of both gender, aged I month – 14 years with seizures were included, included in the test and non seizures in control category. After through clinical examination venous blood samples were collected for the estimation of serum electrolyte levels, 24 hours after onset of seizures on admission. T test was used to find the statistical significance and p > 0.05 was considered statistically significance. The mean age was 8.6 and 7.8 years respectively in test and control groups. Seizures were diagnosed to be due togliosis, mesial temporal sclerosis, infarcts, hippocampal sclerosis, leighs disease.Statistically there was significant difference between the serum electrolyte levels.There was decrease in serum Ca and Mg levels with seizures. However, there was no correlation between serum electrolytes and severity of seizures.