Biologically synthesized metal-nanoparticles, has a significant role in the application of modern nanobiotechnology due to its potential ability to synthesis nanoparticle at different size, shape, morphology and texture. In this study, we investigated the synthesis of silver nanoparticles from Bacillus subtilis extracellular, with the help of a bioreduction metal ion into the actively grown culture, in aseptic conditions. Characterized features of synthesized silver bionanoparticles (Ag-BNPs) analyzed by using UV-spectrophotometer, TLC, AFM, and FTIR. The characterization studied of this bacterium reacted on the Ag + ion indicated that the biomolecules might be the responsible for the stabilization of silver nanoparticles. In fact, silver nanoparticle (Ag-NPs) declared as the most effective antibacterial activity when compare to other metal nanoparticles. Antibacterial activities of synthesized silver bionanoparticles against various pathogens were performed by standard Nathan's Agar Well Diffusion (NAWD) technique. These studies suggest that the silver bionanoparticles (Ag-BNPs) can be synthesized from the Bacillus subtilis efficiently and its confirmation, stability over metals, and its characteristic features. This report also reveals that the anti-bacterial activity of nanoparticles against certain pathogens and can be used for the antimicrobial studies and may applied in the field of nanomedicine.

Objective: Curcuma longa is a known natural medicine for inflammation from ancient times. It has a low absorption rate and poor solubility. Hence, it is used for the green synthesis of nanoparticles. Zinc oxide nanoparticle (ZnO NPs) is famous nanoparticles which are economical, less toxic, and brilliantly biocompatible. They have potential biomedical properties, mainly anticancer, antidiabetic, and antimicrobial.Methods: The present study was designed to investigate in vitro analysis of the antimicrobial activity against pathogenic bacteria and fungi and its ability to scavenge reactive oxygen radicals of ZnO NPs.Results and Conclusion: The results indicated that ZnO NPs produced from C. longa had higher antimicrobial activity against Escherichia coli, Staphylococcus aureus, Streptococcus pyogenes, and Candida albicans. Therefore, we suggest that ZnO NPs can be used as the antimicrobial agent. It is a good scavenger of superoxide radical, nitric oxide, and hydrogen peroxide and has reducing power, which is greater than ascorbic acid at a higher concentration.

Objective: Curcuma longa is a known natural medicine for inflammation from ancient times. It has a low absorption rate and poor solubility. Hence, it is used for the green synthesis of nanoparticles. Zinc oxide nanoparticle (ZnO NPs) is famous nanoparticles which are economical, less toxic, and brilliantly biocompatible. They have potential biomedical properties, mainly anticancer, antidiabetic, and antimicrobial.Methods: The present study was designed to investigate in vitro analysis of the antimicrobial activity against pathogenic bacteria and fungi and its ability to scavenge reactive oxygen radicals of ZnO NPs.Results and Conclusion: The results indicated that ZnO NPs produced from C. longa had higher antimicrobial activity against Escherichia coli, Staphylococcus aureus, Streptococcus pyogenes, and Candida albicans. Therefore, we suggest that ZnO NPs can be used as the antimicrobial agent. It is a good scavenger of superoxide radical, nitric oxide, and hydrogen peroxide and has reducing power, which is greater than ascorbic acid at a higher concentration.

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