The occurrence of opportunistic infection is largely seen in immunocompromised patients. Varicella infection is one such infection caused by Varicella Zoster Virus (VZV) -a human neurotropic virus which primarily presents as varicella or chickenpox and remains in dormant stage which reactivates showing as the leading cause for viral encephalitis. This case demonstrates a 32 years male patient who was presented with fever, chills, urinary retention, giddiness and vascular lesions on body. The patient was diagnosed as varicella zoster infection with the evidence of Polymerase chain reaction (PCR) of Cerebrospinal fluid (CSF) and started with ACYCLOVIR injection 500 mg. Later based on magnetic resonance imaging (MRI) scan results patient was found to have Tuberculosis meningitis and CD4 count human retrovirus (HIV) report reviled HIV. Gradually patient started developing rashes on genitals diagnosed as Verruca Vulgaris. The patient was on symptomatic therapy with anti tuberculoid (AKT 4 kit) with plan to start Anti-retroviral therapy (ART) after 2weeks.